After disinfection, it is recommended to deactivate and then reactivate System Restore (to clean it) as sometimes the restore points can be infected.
Click the Vista logo right-click "Computer" then click "Properties"
Click "System Protection"
Uncheck the box of the disk(s) for which you want to disable System Restore:
A confirmation is required and inform you that the existing restore points will be deleted without any possibility of backtracking:
To reactivate System Restore, just check the box again but this does not recover the old points system restore.