Well, I am running a Toshiba Satellite P300 and I am having this same problem and no combination of Ctrl, Alt, Shift, Num Lock, or any of the F keys has been able to fix this problem. I just got it back from repair and they changed the mother board. I have updated the bios. I did a fresh OS install to Vista that came with my computer. Even upgraded to Windows 7. I didn't have this problem before it went out for repair, but now when I press the Num Lock key, it changes my number pad to numbers, as expected, but also changes the right side of my keyboard to numbers as well which is very frustrating. I have been surfing for 2 days online to find a solution to it and even called the tech that was in charge of the repair and no one has any answers for me.