We are missing some information here and we can't guess.
Is this for all of your programmes or one in particular ?
When you try to run the .exe do you get an error message? What does it say?
What is the make and model of your computer?
What is your operating system?
What is your antivirus software ? Is your antivirus running ?
Do you have access to internet?
P.S. Please, bare in mind that CCM is a mutual aid community, all answers on the forum are provided by volunteers who give their time free to help solve issues.
Hence we request that CCM forum users show mutual respect. Therefore, when asking for assistance, please be courteous, as for elsewhere in similar circumstances in every day society when asking for help. (Usually, how would someone ask for help? i.e. please, thank you, appreciate, grateful, etc.)
Being courteous will also increase your chances of getting the help you need.