Missing bios or boot file

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Hello,
Please I have an acer aspire v5-122p laptop. When turned on ur doesn't get pass the acer sign then says no boot media or file found. Then a black screen saying please restart pc.. Changed hard drive yet still the no change

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OK, so you changed the hard drive. In bios, does it see it? If not, then motherboard is bad, drive is bad (probably not as that would be two bad drives), or the sata cable isn't seated against the motherboard.

If the bios can't see it, then you can't load a new OS onto that new hard drive you installed! Unless, there is no Os on the new drive, in which case you will get the same error (as if it is bad!) What operating system is on the new drive?
I think this started when the usb ports stopped working showing error code 43.. Windows 8.1 & 10
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So, we are talking about a USB external hard drive, for like backups and such?

If the USB ports are bad, then it sounds like the whole MB is flakey!