My computer won't run programs!

Hello,
I rebooted my computer about a day ago because of a critical update. When i turned it back on, it wouldn't open any programs. So, i try and fix it. I can open programs on safe mode though. What then happens is when i try to scan it with McAfee or Malwarebytes it freezes about an eighth of the way through scanning it on both programs. When I try the system restore it says that an error has occured because some file was unable to be restored on both restoration dates. What can i do? Thanks :D