NOD32 Offline Update 4769 (20100113) will find your %SystemDrive% and create the correct folder, put the latest updated defs and module files in it (delete older files if present) then change the update server details in the registry; (no manually setting up server) so all you have to do is click update in NOD32.
And its portable so no need to install
Run it from a CD, USB stick, DVD, Local drive, USB drive and more.
NOD32 Offline Update 4769 will update the following:
Virus signature database:
Advanced heuristics module:
Anti-Stealth support module:
Archive support module:
Personal firewall module:
System status module:
Self-defence support module:
Antivirus and antispyware scanner module:
ALL updated defs and module files are MD5 checked on running of the program (This is not just RARed files like others)