Regarding email notification in Excel 2010

Hello,
I am preparing a sheet for my company leaves and in this sheet I want users to put their leave date and once they make changes in the leave it should go to their respective managers email id .Managers email id is mentioned in one of the column in Excel.

Can you please let me know how I can create Macros for sending email notification to respective managers mentioned in one column after saving the sheet?

Your quick response will be really helpful.

Thanks & Regards,
Ansha Agrawal