Yes, I was struggling to get my E: drive to work again but I succeeded.
This is what I did:
(Windows 10 that is)
1 I right clicked START MENU 2 Chose "Disk Management"
3 When it opened up, I deleted the disk I was having problem with (You do that by right-clicking the disk and pressing "Delete volume"). When you do that there will be still shown the disk's max. space. Right click on that and choose "Create volume", really you can't miss it, it's the only option when you right click it. You are then going to be guided by wizard on how to install it. And then wait while it formats it self.